Open access
Aug 2026
Chimeric Induced Cooperativity Opens the Design Space of Eukaryotic Gene Regulation
Chimeric induced cooperativity (CIC), a modular architecture that separates LBD, DBD and AD functions and links them to promoters with tunable basal and maximal output, is established, a programmable, model-guided design space for eukaryotic transcriptional control.
Yi-Yan Zhan, Zeng-Li Li, Xin-Rui Li et al.
· bioRxiv · 0 citations