Open access
Aug 2026
Cascade-coupled colorimetric-fluorescent dual-signal detection of EGFR-positive extracellular vesicles via bifunctional MOF@Pt nanozyme integrated with a CHA-CRISPR system.
A platform that integrates a bifunctional nanozyme system with a CHA-CRISPR/Cas12a cascade, achieving selective isolation and ultrasensitive detection of EGFR-positive glioma-derived EVs and offers a potentially adaptable framework for cascade-coupled dual-signal biosensing is developed.
Yan Wang, Bo-Ya Xu, Zehan Zeng et al.
· Biosensors & bioelectronics · 0 citations