Open access
Sep 2026
HMGB1 induces mitochondrial dysfunction through the TLR4 and RAGE pathways to promote astrocyte autophagy and PANoptosis in intracerebral hemorrhage.
In the acute phase of ICH, HMGB1 promoted poor prognosis by mediating mitochondrial dysfunction through the TLR4 and RAGE pathways, thereby promoting autophagy and PANoptosis while increasing neuroinflammation after ICH.
Wen-Zuo Shang, Jing-Yu Cui, Xue-Ling Bai et al.
· Chinese Medical Journal · 0 citations