Aging of Mesenchymal Stem Cells in Bone Aging: Mechanisms, Impact, and Therapeutic Perspectives.
Aging of the skeleton is a hallmark of organismal decline and underlies prevalent age-related disorders such as osteoporosis and osteoarthritis. Bone marrow-derived mesenchymal stem cells (BMSCs), the primary source of osteoblasts, undergo profound functional deterioration during senescence, leading to an imbalance bet...