CODesign: Consistency from Data to Trajectory in All-Atom Protein Binder Co-Design
The central challenge in de novo protein design is generating plausible, mutually compatible structures and sequences, such that each designed sequence folds into its intended structure and the structure accommodates that sequence. Compared to typical two-stage design methods, which decouple the modeling of the interde...
Yuan-Le Mo, Bo Qiang, Hai-Tao Lin et al.
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