Open access
Aug 2026
Acetoacetate–GPR43 axis epigenetically silences IL-6/CSF1 to restrict TAMs-driven metastatic lung cancer
A previously unappreciated collapse of acetoacetate homeostasis in lung cancer is uncovered, driven by the coordinated suppression of ketogenesis and increased ketolysis, resulting in a systemic acetoacetate deficiency.
Shuying Yuan, Biying Xiao, Shuai-Shuai Ni et al.
· Journal of Translational Med... · 0 citations