Lipoprotein trafficking is essential for Gram-negative bacteria to maintain the outer membrane, a permeability barrier critical for survival and antibiotic resistance. While most bacteria employ the canonical LolCDE transporter, Acinetobacter utilizes a noncanonical LolDF system whose mechanism has remained unclear. He...
Jie Pang, Ya-Wen Chen, Wen-Long Qiao et al.· Nature Communications· 0 citations
The β-barrel assembly machinery (BAM) is essential for outer membrane protein (OMP) biogenesis in Gram-negative bacteria and represents a validated target for antibiotic development. Its evolutionary relative, the translocation and assembly module (TAM), is thought to assemble OMPs but through a mechanism that remains...
Clonally expanded CX3CR1‐expressing CX3CR1‐expressing CD4+ and CD8+ T cells are identified as a core disease‐associated effector population, highlighting a disease‐associated inflammatory T cell state linked to peripheral immune activation and CNS immune remodeling, with potential translational relevance for future bio...
Lin Yan, Er-Di Zhang, Yuwen Ma et al.· Advancement of science· 0 citations
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