Bing-Yi Zhang

Explainable machine learning integrating CT-derived intratumoral heterogeneity for histological subtype prediction in pure ground-glass lung adenocarcinoma: multicenter validation and transcriptomic characterization

Background Preoperative differentiation of lepidic-predominant adenocarcinoma from other histological subtypes in lung adenocarcinoma presenting as pure ground-glass nodules remains challenging. We evaluated whether a CT-derived intratumoral heterogeneity score provides complementary predictive and biological informati...