Chicken IDO2 and TDO2: Biochemical Characteristics and Regulatory Roles in Avian Tryptophan Metabolism and Inflammatory Response
Simple Summary Indoleamine 2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase (TDO2) serve as rate-limiting enzymes for the kynurenine pathway. Distinct from mammals, chickens lack the IDO1 gene and rely exclusively on IDO2 and TDO2 for tryptophan catabolism. Supplemental dietary tryptophan increases the combined...