Epidermal HLA-DQB1 exerts negative regulation of mast cell activation through the TSLP-driven SPP1-expressing macrophage axis.
BACKGROUND Keratinocytes(KCs) and the major histocompatibility complex class II (MHC-II) are implicated in inflammatory skin diseases. However, the precise expression profiles and causal role of keratinocyte -intrinsic MHC-II in urticaria remain largely undefined. OBJECTIVE To investigate the causal relationship and...