A Mitochondria-Targeted and pH-Responsive Fe3+-Astragalin Nanoplatform Reprograms Metabolism to Protect Against Acute Kidney Injury.
Acute kidney injury (AKI) is a life-threatening clinical syndrome characterized by abrupt renal dysfunction, excessive oxidative stress, inflammatory activation, and profound metabolic disturbances, yet effective therapeutic strategies remain limited. Herein, we developed an ultrasmall pH-responsive nanoplatform (FeAst...