Open access
Aug 2026
Targeting CPSF73, the mRNA 3’ end processing endonuclease, moves cancer cells away from the mesenchymal state
Background Metastasis significantly contributes to cancer-related mortality and therapeutic failure. Cancer cells acquire metastatic potential by losing epithelial characteristics and gaining mesenchymal properties through the epithelial-mesenchymal transition (EMT). Differential poly(A) site (PAS) usage, known as alte...
Marzieh Naseri, Huiyun Liu, Luyang Wang et al.
· Frontiers in Immunology · 0 citations