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Bin Lu

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Open access Aug 2026

DHST: A Deep Hybrid Structure–Topology Framework for Accurate Protein Function Prediction

DHST is proposed, a deep hybrid structure–topology framework that integrates sequence semantics from a pretrained protein language model with local structural information learned by a residual graph convolutional network and introduces site-specific persistent homology to encode multi-scale topological invariants and a topology-guided residue-wise gated fusion module to modulate structure–semantics representations using local topological embeddings.

Bin Lu, Fujun Xiang, Hai-Long Wang et al. · 0 citations

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