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Open access Sep 2026

Early molecular changes in the subfornical organ during experimental autoimmune encephalomyelitis.

Experimental autoimmune encephalomyelitis (EAE) is a commonly used animal model of multiple sclerosis that allows the investigation of early immune-neural interactions that may precede clinical symptoms. The subfornical organ (SFO), a sensory circumventricular structure devoid of a blood-brain barrier, is anatomically...

Jing-Jing Zhou, Li-Xia Zhou, Kai-Yue Song et al. · 0 citations
Open access Aug 2026

Obinutuzumab β for aquaporin-4-positive neuromyelitis optica spectrum disorder: a phase 3 randomized controlled trial.

Although CD20-directed B cell depletion has long been used in neuromyelitis optica spectrum disorder (NMOSD), high-quality, large-scale, randomized controlled trials remain limited. In this multicenter, randomized, double-blind phase 3 trial, we evaluated obinutuzumab β (MIL62), a novel glycoengineered type II anti-CD2...

Lei Wu, Liangliang Gu, Wei-Hao Fan et al. · 1 citation
Open access Sep 2026

Elevated ISG15 reinforces RIG-I/MDA5-linked macrophage-microglia crosstalk during blood-brain barrier disruption in neuromyelitis optica spectrum disorder.

BACKGROUND Neuromyelitis optica spectrum disorder (NMOSD) is an AQP4-IgG-mediated astrocytopathy characterized by blood-brain barrier (BBB) injury and myeloid inflammation. We investigated whether interferon-stimulated gene 15 (ISG15) contributes to myeloid activation through RIG-I-like receptor (RLR) signaling. METH...

Yunfeng Niu, Jing Sun, Yu-Sen Han et al. · 0 citations

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