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Author

Bin Le

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Open access Sep 2026

A lactate-HIF1α-VDR positive feedback loop drives protective SPP1⁺ macrophage differentiation to inhibit schistosomiasis-induced liver fibrosis

It is shown that vitamin D receptor (VDR) signaling in macrophages is essential for limiting fibrosis, acting through a previously unrecognized metabolic-epigenetic circuit and identified macrophage VDR as a promising therapeutic target for fibrotic liver diseases.

Zhou Xing, Ping T. Yang, Hui-Yu Xia et al. · 0 citations

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