Open access
Sep 2026
CryoFlex characterizes structural motion between conformations directly from cryo-EM density maps
Heterogeneous cryo-EM reconstruction methods can resolve multiple conformational states, but understanding their functional implications often requires determining which regions move between states and quantifying their displacement magnitudes. Comparing atomic models can quantify motion, but flexible regions are often...
Hao Dong, Fu-Wei Li, Yuan-Bo Chen et al.
· bioRxiv · 0 citations