Bin-Bing Liu

Diffusion-based self-supervised adaptive denoising for live-cell fluorescence microscopy

To mitigate phototoxicity, photobleaching, and motion blur, long-term live-cell fluorescence imaging is typically performed with low excitation intensity and short exposure times, resulting in extremely low and progressively decaying signal-to-noise ratio (SNR). Meanwhile, the inherent irreproducibility of biological p...