Bin-Bin Pan

Proximity-Induced Disulfide Rebridging Enables Modular Construction of Stable Antibody-Drug Conjugates.

Disulfide rebridging chemistry is a promising strategy for site-specific modification of native antibodies. Current disulfide rebridging strategies using homofunctional rebridging reagents typically favor either rapid conjugation with compromised stability or stable linkage formation with reduced reaction efficiency. H...