#protein folding
Oct 2026
Temporally Validated Models for Target “Tclin-likeness”
Abstract Identifying which human proteins are likely to become validated drug targets remains a challenge in drug discovery. We build on the “Tclin” concept, which encompasses proteins for which at least one approved drug exerts its mode of action (MoA); these comprise only ∼3% of the human proteome. We developed disea...
Mohammed A. Quazi, Suman Sirimulla, Cristian Bologa et al.
· Journal of Chemical Informat... · 0 citations