Bijaya Gaire

MEKing Room: On the Quest for New Sources of Therapeutic Index in RAS/MAPK-Driven Cancers.

The RAS/MAPK pathway is among the most frequently dysregulated in human cancer, predominantly driven by activating mutations across RAS and BRAF in a broad spectrum of tumor types. The recent clinical validation of direct inhibitors of RAS, long considered undruggable, has reenergized the field and renewed focus on tar...