Author

Bianca Colalillo

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Open access Oct 2026

PTPN2 sustains non-canonical inflammasome activation and shapes the inflammatory response to sepsis

The innate immune system relies on pattern recognition receptors to recognize and detect pathogens. Gram-negative bacteria release LPS-rich outer membrane vesicles (LPS-OMVs), which activate PRRs, trigger inflammation at distant sites and contribute to systemic inflammatory conditions like sepsis. Inflammasomes, ce...

Bianca Colalillo, Isabelle Aubry, Philippe Aumont et al. · Cellular and Molecular Life... · 0 citations

Open access Aug 2026

Ptpn2 limits plasma cell fate and antiviral immunity by integrating B cell receptor and IFN-γ signals in B cells

Antigen-specific humoral responses are critical for long-term protection against infectious diseases, yet the mechanisms that regulate B cell differentiation and antibody production remain incompletely defined. Here, we identify the Protein Tyrosine Phosphatase Nonreceptor Type 2 (Ptpn2) as a B cell–intrinsic regulator...

Ana Maria Hincapie, Alexandre Poirier, Isabelle Aubry et al. · Science Advances · 0 citations