Open access
Sep 2026
Constrained diffusion-enabled construction of a highly expressed and robust peptide asparaginyl ligase
Peptide asparaginyl ligases (PALs) hold great promise for peptide macrocyclization and protein bioconjugation, yet their broader application is limited by insufficient thermal stability and low recombinant expression. Here, we report FortiPAL-1, a diffusion-enabled PAL developed through an integrated computational-expe...
Shuo Pang, Yu-Xing Hao, Jia-Rong Mo et al.
· Chemical Science · 0 citations