Emerging chemical strategies for modulating protein O-GlcNAcylation.
O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) is an essential and dynamic post-translational modification (PTM) that modulates diverse cellular processes. Dysregulation of O-GlcNAcylation is associated with numerous human diseases, yet no O-GlcNAc-targeting therapy has been approved for clinical use, un...