This study identifies TTK as a prognostic LUAD biomarker regulated by a ceRNA network, driving immune evasion and therapeutic resistance.
An integrated in silico approach was employed using OncoMX, KM Plotter, UALCAN, and GEPIA2 for expression and survival analysis. Protein expression and promoter methylat...
Prachi Patidar, Bhavika Baweja, Chainsee Saini et al.· Journal of Cancer Research a...· 0 citations
Circular RNAs (circRNAs) are endogenous, covalently closed RNA molecules generated through back-splicing that exhibit exceptional stability, evolutionary conservation, tissue-specific expression and diverse regulatory functions. Compared with conventional RNA-based therapeutic platforms, such as messenger RNAs (mRNAs),...
Niranjan Kumar, Chainsee Saini, Rashi Soni et al.· Frontiers in Pharmacology· 0 citations
An integrated view of MELK dysregulation in LUAD is provided, linking its G2/M-associated activity with post-transcriptional regulation, immune features, and potential therapeutic targeting.
Kritika Jangir, Niranjan Kumar, Chainsee Saini et al.· Frontiers in Oncology· 0 citations
A comprehensive perspective on MELK is offered that stands out in the existing literature for its critical evaluation of context-dependent functions and therapeutic relevance and highlights key gaps that must be addressed to establish MELK as a reliable cancer biomarker and therapeutic target.
Kritika Jangir, Prachi Patidar, Bhavika Baweja et al.· Frontiers in Oncology· 0 citations
This review consolidates current knowledge of TTK function beyond its canonical SAC activity, emphasizing its emerging roles in DNA damage response, epithelial-mesenchymal transition, and oncogenic signaling pathways.
Prachi Patidar, Kritika Jangir, Chainsee Saini et al.· Cell Communication and Signa...· 0 citations
A robust G2/M -associated regulatory framework in LUAD is defined, characterized by reciprocal dysregulation of oncogenes and tumor suppressors and associated with the predicted TMPO-AS1–hsa-let-7b-5p regulatory network, which is linked to a less immunosuppressive tumor microenvironment, offering potential prognostic a...
