Antigens of intracellular origin are processed then presented by proteins of the highly polymorphic major histocompatibility complex I (MHCI), thereby enabling T cell activation during an immune response. In particular, the peptide-exchange catalyst tapasin (Tsn) plays a critical role in shaping the pool of peptide ant...
Alexandra Mitlehner, Aldo S. Pasos-Trejo, M. Becker et al.· Nature Communications· 0 citations
Recent advances in AI-based computational enzyme design are presented, discussing the main challenges in the field and how a combination with classical physics-based methods could help overcome them.
Rosa Teijeiro-Juiz, Thomas B Brück, Bernhard Loll· Molecules· 0 citations
A comprehensive introduction and overview of several current artificial intelligence (AI)‐driven methods available for enzyme design, with a focus on reaction‐to‐sequence design, structure prediction, substrate scope prediction, engineering of stable variants, design of enzymes with non‐canonical amino acids, and de no...
Rosa Teijeiro-Juiz, Nina Egeler, Grzegorz Jamróg et al.· Protein Science· 2 citations
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