Sep 2026
Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer’s vulnerability
Bernard Mulvey, Heena R. Divecha, M. Tippani et al.
· Acta Neuropathologica · 0 citations
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Feb 2026
Pathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimer’s disease
It is demonstrated that pTau triggers phenotypes reflective of LC-NE hyperactivity in the early stages of AD pathogenesis, laying the foundation for the development of LC-based disease-modifying therapies to address neuropsychiatric manifestations.
Anuradha Korukonda, Harris E. Blankenship, K. Kam et al.
· bioRxiv · 3 citations