Benjamin Shang Yong Au-Yeung

Gentamicin and d-serine selective pressure to improve the homogeneity of cells expressing target proteins

Findings support the use of selective pressure to reduce recombinant expression heterogeneity and suppress low-expression subpopulations and highlight the potential use of d-serine and similar toxic substrates to simultaneously function as selective agents, inducers, and sources of essential metabolites through detoxification.