Linker histone H1 is an essential chromatin architectural protein that compacts chromatin into transcriptionally silent regions by interacting with nucleosomal and linker DNA while rapidly exchanging in vivo. How H1 targets nucleosomes while being dynamic remains unanswered. Using a single-molecule strategy, we investi...
E. Akbari, Nathaniel L. Burge, M. Valdimarsson et al.· Molecules and Cells· 0 citations
Residue-level coarse-grained simulations provide a powerful route for modeling biomolecular condensates over length and time scales that are difficult to access with atomistic molecular dynamics. Coarse-grained models have been shown to reproduce many aspects of equilibrium phase behavior. However, it remains unclear t...
Soundhararajan Gopi, Han-Ling Qin, Robert B. Best et al.· bioRxiv· 1 citation
Single-molecule spectroscopy is emerging as a powerful approach for elucidating the molecular structure and dynamics of biomolecular condensates. Unlike ensemble methods, it can resolve heterogeneous conformations, dynamics, interactions, concentrations, and transport properties across a broad range of length- and time...
Benjamin Schuler, Aritra Chowdhury, Miloš T. Ivanović et al.· Current Opinion in Structura...· 0 citations
All-atom simulations with explicit solvent can provide a detailed and accurate description of dynamics and mechanisms in biomolecular systems, including intrinsically disordered proteins (IDPs) and their condensates. However, interactions involving charged residues and ions remain a persistent source of systematic erro...
Miloš T. Ivanović, Valentin von Roten, Benjamin Schuler et al.· bioRxiv· 0 citations
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