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This study provides a hypothesis-generating framework for future biomarker-guided combination strategies, which requires validation in HER2-positive cohorts and experimental models.
The designed MEV and identified immunogenic targets represent promising vaccine candidates against S. maltophilia, offering safer and more specific therapeutic avenues, and nine novel drug targets were predicted for S. maltophilia, providing new therapeutic insights.
Combined genomic surveillance and structural analyses demonstrated that the investigated Omicron-associated mutations largely preserved the overall architecture of the M protein-Fab interaction interface while modulating residue-level energetic contributions and the conformational dynamics of the E protein.
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