Proteolytic Activation of T Cell Engagers And Bispecific Proteins Using Modular Coiled-Coil Peptides.
Bispecific T cell engagers (BiTEs) are engineered immunotherapeutic molecules designed to direct the body's immune system against malignant cells by physically connecting T cells to target cells, triggering cytotoxic responses. BiTEs have typically engaged T cells via αCD3 domains, such as OKT3 or UCHT1, which are link...
Basudeb Mondal, Yusef A. Haikal, Gabriel A. Kwong et al.
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