Lamotrigine Attenuates Lipopolysaccharide-Induced Working-Memory Impairment and Is Associated with Changes in Neuroinflammatory, Oxidative-Stress, and Apoptosis-Related Markers
Highlights What are the main findings? Lamotrigine (LTG) ameliorated lipopolysaccharide (LPS)-induced working-memory impairment and suppressed neuroinflammatory responses in the prefrontal cortex. LTG reduced oxidative stress and pro-apoptotic signaling while restoring endogenous antioxidant and anti-apoptotic defenses...