Author

Barbora Havlinova

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Open access Oct 2026

Elevenostat Is an HDAC6/Class I-Biased Multi-HDAC Inhibitor Rather than an HDAC11-Selective Chemical Probe.

Histone deacetylase 11 (HDAC11) is a lysine defatty-acylase with emerging roles in immunity, metabolism, and disease, creating a need for rigorously validated isoform-selective inhibitors. Elevenostat/JB3-22 has been used as an HDAC11 inhibitor, but its HDAC isoform selectivity has remained insufficiently defined. Here...

M. Vošahlíková, Zsófia Kutilová, Júlia Kudláčová et al. · ACS Chemical Biology · 0 citations

Aug 2026

Tuning HDAC Inhibition, Cell Uptake, and Antiproliferative Activity of Vorinostat-Derived Half-Sandwich Complexes with Phosphine Co-Ligands.

To alter the interactions between HDACs and half-sandwich organometallic HDACis, amphiphilic 1,3,5-triaza-7-phosphaadamantane (PTA) or lipophilic triphenylphosphine (PPh3) as coligands were introduced or Rh(III) derivatives exhibited promising antiproliferative and HDAC inhibitory activity compared to their chlorido pr...

Chen Chen, Barbora Havlinova, M. Vošahlíková et al. · Inorganic Chemistry · 0 citations