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Barbara B. Bendlin

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Oct 2026

EXPRESS: Synaptic density PET mediates the relationship between Alzheimer's disease pathology and cognitive performance.

INTRODUCTION Synaptic loss is one of the strongest post-mortem predictors of Alzheimer's disease (AD) severity and may impact how pathology affects cognition. This study compared regional [11C]UCB-J synaptic density across the AD continuum and evaluated the extent to which synaptic density mediates relationships betwee...

Max J. McLachlan, Brecca Bettcher, Rebecca E. Langhough et al. · 0 citations

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