Author

Bao-Yi Huang

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Review Open access Sep 2026

Hydrogen releasing biomaterials for bone regeneration: mechanisms, design strategies, and applications

Complex bone defects remain major clinical challenges due to their multifaceted pathological microenvironment. In recent years, hydrogen (H2) therapy has emerged as a rapidly developing strategy for bone repair, leveraging its redox-regulatory and other microenvironment-modulating effects. However, the rapid diffusion...

Yan-Shan Chen, Yuan-Yuan Yin, Bao-Yi Huang et al. · Bioactive Materials · 0 citations

Sep 2026

An integrated engineering strategy enhances expression and activity of Pseudonocardia thermophila nitrile hydratase in Escherichia coli.

Nitrile hydratase is a key enzyme for nitrile-to-amide hydration under mild conditions, yet its application is limited by low heterologous expression, poor solubility, and suboptimal catalysis. Here, we present an integrated strategy to enhance expression, assembly, and function of Pseudonocardia thermophila NHase (PtN...

Xiao-Ling You, Yu-Qing Chen, Zi-Ying Tan et al. · International Journal of Bio... · 0 citations