βKlotho filters ligand-independent FGFR1/4-PLCγ signaling to prevent aberrant constitutive Ca2+ entry.
Fibroblast growth factor receptors 1 and 4 (FGFR1/4) regulate diverse cellular processes, including proliferation, differentiation, and metabolic homeostasis. Although ligand-dependent FGFR signaling has been extensively characterized, the signaling properties of these receptors in their ligand-independent state remain...