Author

Baoqing Tian

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Open access Sep 2026

ITGA5 promotes homologous recombination mediated radioresistance in esophageal squamous cell carcinoma by upregulating RAD51AP1 expression.

Radiotherapy resistance represents a critical barrier to successful treatment of esophageal squamous cell carcinoma (ESCC), driving tumor recurrence and poor patient survival. We identify constitutive overexpression of integrin α5 (ITGA5) as a key molecular determinant of ESCC radioresistance. Clinically, elevated ITGA...

Xin-Yi Huang, Jia-Yi Liu, Jiao Ren et al. · Oncogene · 0 citations

Open access Jul 2026

SNORA23-KDM5C epigenetic axis mediates dual DNA repair pathways to drive radioresistance in esophageal squamous cell carcinoma.

A snoRNA-chromatin-repair axis driving therapeutic resistance and support SNORA23 inhibition as a promising strategy to overcome radioresistance in ESCC are defined.

Bao-Qing Tian, Hua Zhang, Jiao Ren et al. · Cell Death and Differentiati... · 0 citations