Open access
Oct 2026
Identification of potential pathogenic genes for lung adenocarcinoma induced by 6PPD-quinone through network toxicology and SHAP analysis
GPI, FAM83D, and ABCC2 are identified as potential pathogenic genes linking 6PPD-quinone exposure to LUAD, possibly through genetic dysregulation, offering new insights into the health risks of tire-derived pollutants.
Xiang Xiong, Jian Ding, Wen Liu et al.
· Frontiers in Toxicology · 0 citations