Review
Open access
Oct 2026
Piezo1-centered mechanotransduction in knee osteoarthritis: multicompartment mechano-inflammatory networks and therapeutic opportunities
Knee osteoarthritis (KOA) is increasingly recognized as a whole-joint mechano-inflammatory disorder in which abnormal loading, tissue remodeling, and inflammatory sensitization reinforce one another. Piezo1 is a context-dependent mechanotransduction hub that links mechanical cues to Ca 2+ -dependent inflammatory,...
Jing Li, Bo Dong, Xue-Qin Zeng et al.
· Arthritis Research & The... · 0 citations