Author

Bailey A. Bye

2 papers indexed here

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Sep 2026

Abstract A118: Leveraging metabolic restriction in cooperation with SHP2 deficiency to inhibit PDAC

SHP2 (Ptpn11) is a tyrosine phosphatase well defined by its role in the MAPK pathway, including modulation of KRAS activity. KRAS is mutated in >90% of Pancreatic Ductal Adenocarcinoma (PDAC), which is the third leading cause of US cancer deaths. Mutant KRAS drives uncontrolled cell proliferation and cancer growt...

McKinnon Walsh, Austin E. Eades, Bailey A. Bye et al. · Cancer Research · 0 citations

Sep 2026

Abstract A048: TGFBR2 dysfunction rewires cell cycle, MAPK signaling, and migration in pancreatic cancer

Genetically engineered mouse models of PDAC exhibit marked differences in survival, indicating that certain genetic alterations regulate disease progression. KC (Ptf1a Cre/+; LSL-Kras G12D/+) mice that possess wildtype transforming growth factor-beta receptor 2 (TGFBR2) have a median survival of 13 months, wherea...

Vincent Lam, R. M. Walsh, Bailey A. Bye et al. · Cancer Research · 0 citations