Auditing Protein-Protein Interaction Signals with Sparse Autoencoder Fingerprints
Protein language models have become a dominant foundation for sequence-based protein-protein interaction (PPI) prediction, but their generalization remains limited under stringent evaluation, and benchmark accuracy alone cannot reveal whether a PPI predictor learns partner-specific biological signals or exploits contex...
Weimin Zhu, Shengfan Wang, Xiaojian Liu et al.
· bioRxiv (Cold Spring Harbor... · 0 citations