Author

B. Varghese

2 papers indexed here

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Open access Aug 2026

Targeting HDAC and proteostasis to eradicate quiescent cancer cells

Chemotherapy remains the primary treatment for ovarian cancer (OvCa), and chemoresistance drives patient mortality. Cellular quiescence, reversible exit from the cell cycle, increases chemotherapy resistance as chemotherapies primarily target rapidly proliferating cells. Here, we report that CHD4 and MBD3, components o...

Qi Jiang, M. Ertel, Austin Arrigo et al. · Cancer Gene Therapy · 0 citations

Jul 2026

Cell cycle-coupled transcriptional network regulates human B cell fate bifurcation 2257411

Antibody response quality and durability depend on activated B cells bifurcating into plasmablast (PB) or germinal center B cell (GCBC) fates. PBs are short-lived and secrete low-affinity antibodies, whereas GCBCs undergo somatic hypermutation and selection before potentially generating long-lived plasma cells th...

Nicholas A. Pease, Jingyu Fan, S. Keshari et al. · Journal of Immunology · 0 citations