Background Insulin resistance–related metabolic burden is associated with cognitive aging, but the relevant white matter microstructural features remain unclear. We examined statistical indirect associations between metabolic indices and cognition through tract-level white matter measures, including associations with s...
Huai-Yi Li, Zhi-Liang Tian, Xiao-Qian Wang et al.· Frontiers in Neuroscience· 0 citations
Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer’s disease (AD) and is particularly pronounced in individuals carrying the APOE ε4 allele, but the mechanisms linking APOE ε4 to BBB failure remain unclear. Here we show that astrocyte-derived fibronectin (FN1) is a key mediator of apolipoprotein E4...
P. Bhattarai, E. Yılmaz, Elif Öykü Cakir et al.· Nature Aging· 1 citation
Depression, anxiety, and higher odds of major cardiometabolic disorders were significantly associated, and IL-6 statistically mediated parts of these associations.
Asma Hallab, S. O'Bryant, Kristine Yaffe et al.· Scientific Reports· 0 citations
Findings support the use of biomarker-informed approaches to guide monitoring and therapeutic intervention in appropriately selected at-risk individuals before the onset of clinical symptoms and support the use of biomarker-informed approaches to guide monitoring and therapeutic intervention.
Yue-Xuan Xu, T. I. Gunasekaran, Yian Gu et al.· Lancet Neurology· 1 citation
An approach that uses the collection of accumulated somatic mutations that uniquely labels each clone of cells to track the infiltration of bone-marrow-derived cells into the human brain finds evidence of an influx of bone-marrow-derived cells into the brain in all examined individuals.
Julia A. Belk, Yao-Wen Zhang, Emily E. Reilly et al.· Nature· 2 citations
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