Author

B. Ueberheide

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Open access Aug 2026

Proteomic comparison of hippocampal neurofibrillary tangles in PART, intermediate Alzheimer’s disease and advanced Alzheimer’s disease

By addressing how Aβ accumulation alters the tangle proteome, this study provides mechanistic insights into the expansion of Tau pathology, paving the way towards the identification of biomarkers and therapeutic strategies that would allow for stabilisation of Tau pathology in the elderly.

Manon Thierry, D. Leitner, Kaleah Balcomb et al. · Acta Neuropathologica · 0 citations

Open access Aug 2026

Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer's disease neuropathology: Preliminary observations

It is hypothesized that upstream alterations in these two pathways contribute to hippocampal dysfunction in DS‐AD.

Abigail J. Nordbeck, Mitchell Martá-Ariza, Henric Ek Olofsson et al. · Alzheimer's & Dementia · 0 citations