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B. Ueberheide

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Open access Aug 2026

Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer's disease neuropathology: Preliminary observations

Down syndrome (DS) is caused by a complete or partial trisomy of chromosome 21, resulting in variable intellectual disabilities and a high risk for early‐onset Alzheimer's disease (DS‐AD). Dysregulation of the mammalian target of rapamycin (mTOR) and insulin (INS) signaling pathways has been reported in DS. We hypothesized that upstream alterations in these two pathways contribute to hippocampal dysfunction in DS‐AD.

Abigail J. Nordbeck, Mitchell Martá-Ariza, Henric Ek Olofsson et al. · 0 citations