Author

B. Sharma

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Open access Jul 2026

IFN-α and IFN-β inhibit NLRP1-driven PANoptosis

Type I IFNs are suggested as a potential therapeutic strategy for NLRP1-driven inflammatory diseases by identifying a TLR4–TRIF–IRF3 signaling axis that induces type I IFNs to negatively regulate NLRP1 transcription, thereby blocking NLRP1-driven, caspase-1/caspase-8/RIPK3–dependent PANoptosis.

B. Sharma, Harisankeerth Mummareddy, S. Chadchan et al. · EMBO Reports · 1 citation