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Open access Aug 2026

Metastatic founder cell candidates resemble preimplantation embryonic blastomeres

Disseminated cancer cells (DCC) in non-metastatic carcinoma patient bone marrow (BM) are predictive of metastasis. Those detected by epithelial cytokeratin or EpCAM expression have poorly-characterized transcription profiles due to their extreme rarity: 1∼2 cells per 2x 106 BM cells in every third non-metastatic patien...

Huiqin Körkel-Qu, Elia Raya, M. Gužvić et al. · 0 citations
Clinical trial Sep 2026

Clinical Relevance of Post-Treatment Circulating Tumor DNA Detection in Early Breast Cancer Using a Tissue-Free Epigenomic Assay: A 2-Year Landmark Analysis.

PURPOSE Circulating tumor DNA (ctDNA) may serve as a biomarker to facilitate early identification of asymptomatic distant tumor spread in patients with breast cancer. The primary objective of this study was to assess clinical validity and prognostic value of post-treatment tissue-free ctDNA detection by evaluating its...

T. Friedl, P. Fasching, A. Hartkopf et al. · 0 citations

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