2026
Production of Cell Models with Differential Zygosity Using CRISPR Base Editors.
Shun Zhang, B. P. Hubbard
· Methods in molecular biology · 0 citations
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Open access
Jul 2026
RAPID: evaluation of Cas12a protospacer nicking and chimeric reporters for PAM-independent RNA and DNA diagnostics
RAPID (RNA/DNA Advanced chimeric, PAM-independent, Integrated Nicking, Diagnostics), a nick-tuned, PAM-duplex-mediated platform for PAM-independent RNA and DNA detection and applies it to detect single-point mutations in ssDNA and RNA substrates, a challenge for traditional Cas12 and Cas13 systems.
I. Iwe, Frank X. Liu, A. Corsano et al.
· Nucleic Acids Research · 0 citations
Open access
Jul 2026
CRISPR RNA-independent activation of Cas12a
It is shown that short RNAs can directly occupy the canonical crRNA-binding channel and trigger a catalytically competent trans cleavage state in the absence of PAM recognition or canonical R-loop formation.
I. Iwe, S. Singh, K. Guan et al.
· medRxiv · 0 citations