B. Merkely

Sex Does Not Influence Graft Failure or Functional Recovery After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis

Sex differences in anterior cruciate ligament (ACL) injury risk are well known; however, whether patient sex influences outcomes after ACL reconstruction (ACLR) remains unclear. The purpose of this study was to compare graft failure, knee stability, return to sport (RTS), and functional outcomes between male...

Myeloperoxidase inhibition with mitiperstat in heart failure with preserved or mildly reduced ejection fraction: a randomized phase 2b trial

Integrating volumes into myocardial work: the prognostic role of non-invasive pressure-strain-volume analysis in transcatheter aortic valve implantation.

PSV loop-derived myocardial work detected LV mechanical differences between AS phenotypes and provided independent prognostic value in TAVI candidates, potentially offering a more physiologically accurate assessment of LV function in this population.

Predictors of echocardiographic response in the Budapest-CRT upgrade trial.

BACKGROUND AND AIMS Up to 30% of patients fail to respond after cardiac resynchronization therapy (CRT). While echocardiographic predictors of response are well described in de novo CRT, evidence in CRT upgrade populations remains limited. We investigated predictors of echocardiographic response in the BUDAPEST-CRT Upg...

Survodutide Once Weekly in Adults with Obesity and Type 2 Diabetes.

BACKGROUND For persons living with both type 2 diabetes and obesity, weight management may be the most effective therapy for type 2 diabetes. Glucagon-like peptide-1 (GLP-1) receptor agonists have potent weight-reducing effects, and other mechanisms may confer additional benefits. Survodutide is an investigational gluc...

Work stress and healthy aging: A conceptual framework for the Semmelweis study and the Semmelweis-EUniWell workplace health promotion model program.

Chronic occupational stress is increasingly recognized as a modifiable accelerator of biological aging, yet it remains underappreciated as a target of geroscience-informed public health intervention. This review reframes workplace stress as a life-course determinant of aging trajectories and introduces a translational...

Significance of Cardiac Troponin in Cancer Patients

The pathological conditions that cause elevated serum cardiac troponin levels in patients with malignancies are summarized and the underlying mechanisms at the molecular and cellular levels are explored and potential clinical applications are discussed.

Prophylactic implantation of implantable cardioverter-defibrillator for the primary prevention of sudden cardiac death after myocardial infarction: protocol for systematic review and meta-analysis of randomised controlled trials

A systematic review and meta-analysis will evaluate and provide primary evidence for the effectiveness of prophylactic implantation of TV-ICDs on all-cause mortality in patients who experienced MI, aiming for primary prevention of SCD after MI.