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B. Lambrecht

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Open access Sep 2026

PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity

In-depth spatial profiling identifies PLA2G2D as a TDLN-centred targetable immune checkpoint for cancer immunotherapy and identifies a specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes that is associated with poor prognosis in patients.

A. van Krimpen, Julie Y. Huang, Mike Eterman et al. · 0 citations
Open access Jul 2026

TNFAIP3/A20 dysfunction drives innate and sterile hyperinflammation

It is suggested that in diseases caused by insufficient TNFAIP3/A20 activity, autoantibodies may reflect a downstream consequence of disease rather than a causative driver, suggesting autoinflammatory rather than autoimmune pathology.

Karel F. A. Van Damme, Pieter Hertens, D. Sichien et al. · 0 citations

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