Author

B. Keikhaei

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Open access Oct 2026

Association of TNFAIP3 Polymorphisms With Bleeding Phenotypes and FVIII Inhibitor Development in Patients With Hemophilia A: A Case-Control Study.

BACKGROUND Hemophilia A is an X-linked bleeding disorder caused by factor VIII (FVIII) deficiency. While F8 gene mutations are the primary cause, immune and inflammatory pathways contribute to variability in clinical phenotype and FVIII inhibitor development. TNFAIP3, encoding the immune regulatory protein A20, negativ...

Fatemeh Karimi, N. Saki, Reyhane Khademi et al. · Haemophilia · 0 citations

Review Open access Aug 2026

Drug Repurposing in Sickle Cell Disease: Evaluating Imatinib as a Therapeutic Candidate

Sickle cell disease (SCD) is an inherited hemolytic hemoglobinopathy characterized by chronic hemolysis, vaso‐occlusive pain crises, and progressive organ damage. Hydroxyurea, often combined with analgesics, remains a mainstay therapy, but may provide insufficient relief during active disease episodes. Drug repurposing...

B. Keikhaei, Daryush Purrahman, Najmeh Nameh Goshay Fard et al. · Pediatric Blood & Cancer · 0 citations