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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

B. Höcker

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3 papers indexed here

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Open access Sep 2026

The novel viper FETUA-3 protein evolved a unique mode of inhibiting snake venom metalloproteinases

Molecular innovation and coevolution play major roles in the evolution of biological diversity, yet we have few instances in which we understand the biological and molecular bases of coevolution. Rattlesnakes and other vipers have evolved resistance to their own novel venom metalloproteinase (MP) toxins through the inv...

N. Dowell, Susana Vázquez Torres, Fiona P. Ukken et al. · 0 citations
Open access Sep 2026

Predicting single mutation effects on binding affinity at protein-protein interfaces based on MMPBSA calculations

Accurate prediction of mutation-induced changes in protein-protein affinity remains a central challenge in computational biophysics and protein engineering. Here we present a physics-based scoring method for predicting the effects of single amino acid substitutions on protein-protein and protein-peptide binding affinit...

Jakob Noske, Thibaud Lepoivre, Maxim Janzen et al. · 0 citations
Review Open access Jul 2026

Protein engineering: status report

Protein engineering appears to be entering a golden age, defined by a rapidly accelerating pace of progress, even as significant challenges in design, screening, and real-world application remain.

H. Ai, Frances H. Arnold, Doug Barrick et al. · 0 citations

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